Zbtb16 - zinc finger and BTB domain containing 16

Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; protein C-terminus binding activity; and protein homodimerization activity. Involved in animal organ development; central nervous system development; and regulation of hemopoiesis. Acts upstream of or within several processes, including embryonic pattern specification; limb morphogenesis; and male germ-line stem cell asymmetric division. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia. Orthologous to human ZBTB16 (zinc finger and BTB domain containing 16). [provided by Alliance of Genome Resources, Apr 2022]