Nae1 - NEDD8 activating enzyme E1 subunit 1

Predicted to enable NEDD8 activating enzyme activity; protein heterodimerization activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including mitotic DNA replication checkpoint signaling; neuron apoptotic process; and protein neddylation. Predicted to act upstream of or within apoptotic process. Predicted to be located in early endosome and membrane raft. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human NAE1 (NEDD8 activating enzyme E1 subunit 1). [provided by Alliance of Genome Resources, Apr 2022]