Picalm - phosphatidylinositol binding clathrin assembly protein

Predicted to enable several functions, including SH3 domain binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Involved in several processes, including amyloid-beta clearance by transcytosis; neuron projection morphogenesis; and regulation of amyloid precursor protein catabolic process. Located in clathrin-coated pit and vesicle. Colocalizes with perinuclear region of cytoplasm. Is expressed in several structures, including aorta; heart; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein). [provided by Alliance of Genome Resources, Apr 2022]