Atp1a3 - ATPase, Na+/K+ transporting, alpha 3 polypeptide

Enables P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential and heparan sulfate proteoglycan binding activity. Involved in several processes, including cellular sodium ion homeostasis; regulation of cardiac muscle cell membrane potential; and sodium ion export across plasma membrane. Acts upstream of or within several processes, including adult locomotory behavior; ionotropic glutamate receptor signaling pathway; and learning or memory. Located in several cellular components, including neuron to neuron synapse; photoreceptor inner segment; and sarcolemma. Part of sodium:potassium-exchanging ATPase complex. Is expressed in several structures, including alimentary system; early conceptus; gonad; heart; and nervous system. Used to study alternating hemiplegia of childhood and bipolar disorder. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; bipolar disorder; dystonia 12; and epilepsy. Orthologous to human ATP1A3 (ATPase Na+/K+ transporting subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]