Arhgap35 - Rho GTPase activating protein 35

Enables GTPase activator activity. Involved in several processes, including axon development; establishment or maintenance of actin cytoskeleton polarity; and regulation of plasma membrane bounded cell projection organization. Acts upstream of or within several processes, including negative regulation of Rho protein signal transduction; negative regulation of vascular permeability; and nervous system development. Located in actin cytoskeleton; ciliary basal body; and cytoplasm. Is expressed in central nervous system and eye. Orthologous to human ARHGAP35 (Rho GTPase activating protein 35). [provided by Alliance of Genome Resources, Apr 2022]