Fbxw8 - F-box and WD-40 domain protein 8

Predicted to contribute to ubiquitin-protein transferase activity. Involved in positive regulation of transcription factor catabolic process and protein ubiquitination. Acts upstream of or within labyrinthine layer blood vessel development and spongiotrophoblast layer development. Part of Cul7-RING ubiquitin ligase complex and SCF ubiquitin ligase complex. Is expressed in several structures, including heart; liver; lung; placenta; and spleen. Orthologous to human FBXW8 (F-box and WD repeat domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]