P2rx2 - purinergic receptor P2X, ligand-gated ion channel, 2

Enables extracellularly ATP-gated cation channel activity. Involved in sensory perception of sound. Acts upstream of or within several processes, including response to ATP; skeletal muscle fiber development; and smooth muscle contraction. Located in plasma membrane. Is expressed in facial ganglion; heart; medulla oblongata basal plate mantle layer; and vagus ganglion. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Apr 2022]