Gckr - glucokinase regulatory protein

Predicted to enable several functions, including carbohydrate binding activity; enzyme inhibitor activity; and fructose-6-phosphate binding activity. Involved in positive regulation of glucokinase activity. Acts upstream of or within cellular glucose homeostasis; negative regulation of glucokinase activity; and protein import into nucleus. Located in nucleus. Is expressed in diencephalon lateral wall mantle layer; liver left lobe; liver right lobe; midbrain mantle layer; and retina. Human ortholog(s) of this gene implicated in end stage renal disease and type 2 diabetes mellitus. Orthologous to human GCKR (glucokinase regulator). [provided by Alliance of Genome Resources, Apr 2022]