Glis1 - GLIS family zinc finger 1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including fat cell differentiation; osteoblast differentiation; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of transcription by RNA polymerase II and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; sensory organ; and skin. Orthologous to human GLIS1 (GLIS family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]