Gba2 - glucosidase beta 2

Enables glucosylceramidase activity; glucosyltransferase activity; and steryl-beta-glucosidase activity. Involved in several processes, including glucosylceramide catabolic process; lipid glycosylation; and regulation of protein polymerization. Located in cytosol. Is extrinsic component of Golgi membrane and extrinsic component of endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and neural retina. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 46. Orthologous to human GBA2 (glucosylceramidase beta 2). [provided by Alliance of Genome Resources, Apr 2022]