Madd - MAP-kinase activating death domain

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in anterograde synaptic vesicle transport; execution phase of apoptosis; and regulation of cell cycle. Acts upstream of or within negative regulation of apoptotic signaling pathway. Predicted to be located in nucleus; plasma membrane; and synaptic vesicle. Predicted to be integral component of membrane. Predicted to be active in cytosol. Is expressed in nervous system; sensory organ; and tongue. Used to study type 2 diabetes mellitus. Orthologous to human MADD (MAP kinase activating death domain). [provided by Alliance of Genome Resources, Apr 2022]