P2rx3 - purinergic receptor P2X, ligand-gated ion channel, 3

Enables extracellularly ATP-gated cation channel activity. Involved in modulation of chemical synaptic transmission. Acts upstream of or within several processes, including neuromuscular synaptic transmission; response to ATP; and smooth muscle contraction. Located in Schaffer collateral - CA1 synapse and axon. Is active in hippocampal mossy fiber to CA3 synapse. Is expressed in several structures, including branchial arch; embryo ectoderm; nervous system; retina; and skin. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]