Ikzf3 - IKAROS family zinc finger 3

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II; regulation of B cell differentiation; and regulation of B cell proliferation. Acts upstream of or within response to bacterium. Located in cytoplasm and nucleus. Is expressed in Peyer's patch; genitourinary system; immune system; lung; and spinal cord. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]