Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in central nervous system development and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; future brain; genitourinary system; and retina. Used to study Dandy-Walker syndrome. Orthologous to human ZIC4 (Zic family member 4). [provided by Alliance of Genome Resources, Apr 2022]