Zic2 - zinc finger protein of the cerebellum 2

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in regulation of transcription, DNA-templated; retinal ganglion cell axon guidance; and visual perception. Acts upstream of or within several processes, including cilium organization; nervous system development; and positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; eye; and neural ectoderm. Used to study holoprosencephaly 5 and schizophrenia. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 5. Orthologous to human ZIC2 (Zic family member 2). [provided by Alliance of Genome Resources, Apr 2022]