Sohlh1 - spermatogenesis and oogenesis specific basic helix-loop-helix 1

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and protein dimerization activity. Involved in oocyte differentiation; positive regulation of transcription by RNA polymerase II; and spermatogenesis. Acts upstream of or within oogenesis; ovarian follicle development; and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Is expressed in gonad and hindlimb long bone. Human ortholog(s) of this gene implicated in ovarian dysgenesis 5 and spermatogenic failure 32. Orthologous to human SOHLH1 (spermatogenesis and oogenesis specific basic helix-loop-helix 1). [provided by Alliance of Genome Resources, Apr 2022]