Man1b1 - mannosidase, alpha, class 1B, member 1

Enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Acts upstream of or within ubiquitin-dependent ERAD pathway. Predicted to be located in cytoplasmic vesicle and endoplasmic reticulum quality control compartment. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human MAN1B1 (mannosidase alpha class 1B member 1). [provided by Alliance of Genome Resources, Apr 2022]