Yy1 - YY1 transcription factor

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including immune system development; negative regulation of pri-miRNA transcription by RNA polymerase II; and response to UV-C. Acts upstream of or within with a positive effect on gene expression. Acts upstream of or within several processes, including anterior/posterior pattern specification; camera-type eye morphogenesis; and regulation of gene expression. Located in chromatin and nucleus. Part of PcG protein complex; chromatin silencing complex; and transcription regulator complex. Is expressed in several structures, including brain; early conceptus; embryo mesenchyme; female reproductive system; and hemolymphoid system gland. Used to study pleuropulmonary blastoma. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human YY1 (YY1 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]