Kmt5b - lysine methyltransferase 5B

Enables S-adenosyl-L-methionine binding activity and histone methyltransferase activity (H4-K20 specific). Involved in positive regulation of isotype switching. Acts upstream of or within histone methylation. Located in condensed chromosome, centromeric region. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 51. Orthologous to human KMT5B (lysine methyltransferase 5B). [provided by Alliance of Genome Resources, Apr 2022]