Svil - supervillin

Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to be located in several cellular components, including costamere; cytosol; and nucleus. Predicted to be active in actin cytoskeleton and cytoplasm. Is expressed in several structures, including exoccipital bone; gut; meninges; pharyngo-tympanic tube; and skin. Human ortholog(s) of this gene implicated in myofibrillar myopathy 10. Orthologous to human SVIL (supervillin). [provided by Alliance of Genome Resources, Apr 2022]