Predicted to enable cysteine-type endopeptidase activity; histone binding activity; and thiol-dependent deubiquitinase. Predicted to be involved in histone H2B conserved C-terminal lysine deubiquitination and mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA processing; chromatin organization; and proteolysis. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Orthologous to human USP49 (ubiquitin specific peptidase 49). [provided by Alliance of Genome Resources, Apr 2022]