Wnt5a - wingless-type MMTV integration site family, member 5A

Enables frizzled binding activity; protein domain specific binding activity; and receptor ligand activity. Involved in several processes, including Wnt signaling pathway; heart development; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; positive regulation of protein phosphorylation; and regulation of animal organ morphogenesis. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; limb; and sensory organ. Used to study Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A). [provided by Alliance of Genome Resources, Apr 2022]