Vdr - vitamin D (1,25-dihydroxyvitamin D3) receptor

Enables DNA binding activity and nuclear receptor activity. Involved in regulation of calcidiol 1-monooxygenase activity. Acts upstream of or within several processes, including intestinal absorption; mammary gland development; and positive regulation of apoptotic process involved in mammary gland involution. Predicted to be located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Predicted to be part of RNA polymerase II transcription regulator complex and receptor complex. Predicted to colocalize with caveola. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]