Vav1 - vav 1 oncogene

Enables guanyl-nucleotide exchange factor activity and phosphorylation-dependent protein binding activity. Acts upstream of or within several processes, including integrin-mediated signaling pathway; neutrophil chemotaxis; and positive regulation of natural killer cell mediated cytotoxicity. Located in cell-cell junction. Is expressed in several structures, including dorsal aorta; extraembryonic component; hemolymphoid system; pancreas; and reproductive system. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]