Tsg101 - tumor susceptibility gene 101

Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Apr 2022]