Trpc6 - transient receptor potential cation channel, subfamily C, member 6

Enables store-operated calcium channel activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Located in plasma membrane and slit diaphragm. Is expressed in several structures, including gut; limb; liver; nervous system; and reproductive system. Used to study focal segmental glomerulosclerosis 2. Human ortholog(s) of this gene implicated in chronic fatigue syndrome; focal segmental glomerulosclerosis; focal segmental glomerulosclerosis 2; and nephrotic syndrome type 2. Orthologous to human TRPC6 (transient receptor potential cation channel subfamily C member 6). [provided by Alliance of Genome Resources, Apr 2022]