Tob1 - transducer of ErbB-2.1

Enables SMAD binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of SMAD protein signal transduction. Located in cytoplasm. Is expressed in 1st branchial arch; genitourinary system; limb; sensory organ; and skeleton. Orthologous to human TOB1 (transducer of ERBB2, 1). [provided by Alliance of Genome Resources, Apr 2022]