Tnfaip3 - tumor necrosis factor, alpha-induced protein 3

Enables kinase binding activity and protein C-terminus binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of defense response; and negative regulation of signal transduction. Acts upstream of or within establishment of protein localization to vacuole; positive regulation of cellular protein catabolic process; and protein K63-linked deubiquitination. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; heart; and retina nuclear layer. Human ortholog(s) of this gene implicated in familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3). [provided by Alliance of Genome Resources, Apr 2022]