Acts upstream of or within negative regulation of Wnt signaling pathway and negative regulation of fibroblast growth factor receptor signaling pathway. Located in endoplasmic reticulum. Is expressed in several structures, including embryo ectoderm; embryo mesenchyme; gut; primitive endoderm; and sensory organ. Orthologous to human SHISA2 (shisa family member 2). [provided by Alliance of Genome Resources, Apr 2022]