Tln1 - talin 1

Enables integrin binding activity; phosphatidylinositol binding activity; and phosphatidylserine binding activity. Involved in integrin activation and integrin-mediated signaling pathway. Acts upstream of or within cell-substrate junction assembly and cortical actin cytoskeleton organization. Located in focal adhesion. Is expressed in several structures, including body cavity or lining; cardiovascular system; neural plate; submandibular gland; and vertebral axis musculature. Orthologous to human TLN1 (talin 1). [provided by Alliance of Genome Resources, Apr 2022]