Predicted to enable ISG15 transferase activity and ubiquitin conjugating enzyme activity. Predicted to be involved in protein modification by small protein conjugation. Predicted to act upstream of or within cellular response to DNA damage stimulus and positive regulation of G1/S transition of mitotic cell cycle. Predicted to be active in nucleus. Is expressed in several structures, including eye; genitourinary system; gut; integumental system; and nervous system. Orthologous to human UBE2E2 (ubiquitin conjugating enzyme E2 E2). [provided by Alliance of Genome Resources, Apr 2022]