Terf2 - telomeric repeat binding factor 2

Enables double-stranded telomeric DNA binding activity and protein homodimerization activity. Involved in anterograde axonal transport; negative regulation of telomere maintenance via recombination; and telomeric loop formation. Acts upstream of or within in utero embryonic development; positive regulation of telomere maintenance; and protection from non-homologous end joining at telomere. Located in chromosome, telomeric region and male germ cell nucleus. Is expressed in cerebral cortex and cortical plate. Used to study xeroderma pigmentosum. Orthologous to human TERF2 (telomeric repeat binding factor 2). [provided by Alliance of Genome Resources, Apr 2022]