Tmc8 - transmembrane channel-like gene family 8

Predicted to enable mechanosensitive ion channel activity; protein sequestering activity; and tumor necrosis factor binding activity. Predicted to be involved in several processes, including negative regulation of protein binding activity; regulation of extrinsic apoptotic signaling pathway via death domain receptors; and zinc ion homeostasis. Predicted to act upstream of or within ion transport. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and nuclear membrane. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human TMC8 (transmembrane channel like 8). [provided by Alliance of Genome Resources, Apr 2022]