Rhbdf2 - rhomboid 5 homolog 2

Involved in negative regulation of protein secretion. Located in endoplasmic reticulum membrane. Used to study nonepidermolytic palmoplantar keratoderma. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF2 (rhomboid 5 homolog 2). [provided by Alliance of Genome Resources, Apr 2022]