Sry - sex determining region of Chr Y

Enables DNA binding activity, bending and DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in male sex determination. Acts upstream of or within male gonad development; negative regulation of gene expression; and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including brain; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in 46,XX sex reversal 1; 46,XY sex reversal; and 46,XY sex reversal 1. Orthologous to human SRY (sex determining region Y). [provided by Alliance of Genome Resources, Apr 2022]