Cripto - teratocarcinoma-derived growth factor 1

Enables several functions, including Wnt-protein binding activity; nodal binding activity; and type I activin receptor binding activity. Involved in several processes, including morphogenesis of a branching structure; nodal signaling pathway; and positive regulation of cell migration. Acts upstream of or within several processes, including circulatory system development; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of fibroblast proliferation. Located in several cellular components, including Golgi apparatus; cell surface; and perinuclear region of cytoplasm. Is extrinsic component of plasma membrane. Is expressed in several structures, including blastocyst; brain; embryo mesoderm; extraembryonic component; and heart. Human ortholog(s) of this gene implicated in colon cancer and congenital heart disease. Orthologous to several human genes including TDGF1 (teratocarcinoma-derived growth factor 1). [provided by Alliance of Genome Resources, Apr 2022]