Appl2 - adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

Predicted to enable phospholipid binding activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including adiponectin-activated signaling pathway; cellular response to hepatocyte growth factor stimulus; and regulation of vesicle-mediated transport. Located in early phagosome membrane; macropinosome; and ruffle membrane. Is expressed in several structures, including alimentary system; autopod; brain; neural retina; and ventricular layer. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2). [provided by Alliance of Genome Resources, Apr 2022]