Kdm5a - lysine (K)-specific demethylase 5A

Enables chromatin DNA binding activity and transcription coactivator activity. Involved in circadian regulation of gene expression and negative regulation of histone deacetylase activity. Acts upstream of or within histone H3-K4 demethylation and negative regulation of transcription by RNA polymerase II. Located in nucleus. Part of protein-DNA complex. Is expressed in several structures, including 1st branchial arch; early conceptus; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in ankylosing spondylitis. Orthologous to human KDM5A (lysine demethylase 5A). [provided by Alliance of Genome Resources, Apr 2022]