Spg11 - SPG11, spatacsin vesicle trafficking associated

Acts upstream of or within several processes, including axonogenesis; cholesterol efflux; and motor neuron apoptotic process. Located in several cellular components, including axon; cytosol; and dendrite. Used to study hereditary spastic paraplegia 11. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2X; amyotrophic lateral sclerosis type 5; and hereditary spastic paraplegia 11. Orthologous to human SPG11 (SPG11 vesicle trafficking associated, spatacsin). [provided by Alliance of Genome Resources, Apr 2022]