Cdc73 - cell division cycle 73, Paf1/RNA polymerase II complex component

Predicted to enable RNA polymerase II complex binding activity. Involved in several processes, including cellular response to lipopolysaccharide; endodermal cell fate commitment; and negative regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of apoptotic process; regulation of cell growth; and regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and respiratory system. Used to study hyperparathyroidism. Human ortholog(s) of this gene implicated in hyperparathyroidism and parathyroid carcinoma. Orthologous to human CDC73 (cell division cycle 73). [provided by Alliance of Genome Resources, Apr 2022]