Cilp - cartilage intermediate layer protein, nucleotide pyrophosphohydrolase

Predicted to be involved in cellular response to transforming growth factor beta stimulus; negative regulation of gene expression; and negative regulation of signal transduction. Predicted to be located in extracellular region. Predicted to be active in collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including diaphragm; lower lip; musculoskeletal system; spleen; and tongue. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human CILP (cartilage intermediate layer protein). [provided by Alliance of Genome Resources, Apr 2022]