Tfap2b - transcription factor AP-2 beta

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including artery morphogenesis; inorganic ion homeostasis; and limb morphogenesis. Acts upstream of with a negative effect on negative regulation of apoptotic process. Acts upstream of or within several processes, including animal organ development; fat cell differentiation; and sympathetic nervous system development. Predicted to be active in nucleus. Is expressed in several structures, including genital tubercle; jaw; metanephros; nervous system; and sensory organ. Used to study Char syndrome; angle-closure glaucoma; and patent ductus arteriosus. Human ortholog(s) of this gene implicated in Char syndrome and patent ductus arteriosus. Orthologous to human TFAP2B (transcription factor AP-2 beta). [provided by Alliance of Genome Resources, Apr 2022]