Tcf7l2 - transcription factor 7 like 2, T cell specific, HMG box

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and beta-catenin binding activity. Involved in several processes, including positive regulation of insulin secretion; regulation of transcription, DNA-templated; and response to glucose. Acts upstream of or within several processes, including animal organ development; negative regulation of cellular response to growth factor stimulus; and regulation of cellular biosynthetic process. Located in cytosol and nucleus. Part of catenin-TCF7L2 complex and transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in colorectal cancer; diabetes mellitus (multiple); pancreatic cancer; and prostate cancer. Orthologous to human TCF7L2 (transcription factor 7 like 2). [provided by Alliance of Genome Resources, Apr 2022]