Tcf4 - transcription factor 4

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and TFIIB-class transcription factor binding activity. Involved in positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; and protein-DNA complex assembly. Acts upstream of or within several processes, including negative regulation of angiogenesis; negative regulation of macromolecule metabolic process; and regulation of vascular endothelial growth factor signaling pathway. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Pitt-Hopkins syndrome and schizophrenia. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]