Tbx2 - T-box 2

Enables DNA binding activity and DNA-binding transcription factor activity. Involved in several processes, including circulatory system development; embryonic morphogenesis; and negative regulation of heart looping. Acts upstream of or within several processes, including animal organ development; muscle cell fate determination; and ureteric peristalsis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; embryo mesenchyme; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]