Tbx15 - T-box 15

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within embryonic cranial skeleton morphogenesis. Located in nucleus. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including branchial arch; embryo mesenchyme; facial prominence; genitourinary system; and limb. Orthologous to human TBX15 (T-box transcription factor 15). [provided by Alliance of Genome Resources, Apr 2022]