Brcc3 - BRCA1/BRCA2-containing complex, subunit 3

Predicted to enable enzyme regulator activity; peptidase activity; and polyubiquitin modification-dependent protein binding activity. Predicted to be involved in several processes, including histone H2A K63-linked deubiquitination; mitotic G2 DNA damage checkpoint signaling; and positive regulation of DNA repair. Predicted to act upstream of or within response to X-ray. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of BRCA1-A complex; BRISC complex; and nuclear ubiquitin ligase complex. Is expressed in bladder; male associated reproductive structure; testis; ureter; and urethra of male. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3). [provided by Alliance of Genome Resources, Apr 2022]