Shank2 - SH3 and multiple ankyrin repeat domains 2

Enables ionotropic glutamate receptor binding activity. Involved in several processes, including learning or memory; modulation of chemical synaptic transmission; and synapse organization. Located in several cellular components, including neurofilament; photoreceptor inner segment; and photoreceptor outer segment. Colocalizes with postsynaptic membrane. Is expressed in cerebral cortex. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human SHANK2 (SH3 and multiple ankyrin repeat domains 2). [provided by Alliance of Genome Resources, Apr 2022]