Hdac4 - histone deacetylase 4

Enables several functions, including chromatin binding activity; protein deacetylase activity; and transcription corepressor activity. Involved in regulation of nucleobase-containing compound metabolic process and response to denervation involved in regulation of muscle adaptation. Acts upstream of or within several processes, including negative regulation of osteoblast differentiation; osteoblast development; and regulation of cardiac muscle contraction by calcium ion signaling. Located in several cellular components, including actomyosin; cytosol; and neuromuscular junction. Is expressed in several structures, including alimentary system; early embryo; ganglia; hand; and telencephalon. Used to study eating disorder. Human ortholog(s) of this gene implicated in ataxia telangiectasia; chromosome 2q37 deletion syndrome; eating disorder; and retinal degeneration. Orthologous to human HDAC4 (histone deacetylase 4). [provided by Alliance of Genome Resources, Apr 2022]