Cblb - Casitas B-lineage lymphoma b

Predicted to enable SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway. Acts upstream of or within several processes, including T cell receptor signaling pathway; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in membrane raft and plasma membrane. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Apr 2022]